Nice to talk to you, first of all, I would like to try your service in this assignment and I will wait the feedback from my tutorial, so do the best. Im going to write all details of my assignment and find a writer specialist in Clinical Pharmacy . PART ONE Choose ONE International or National evidencebased guideline for use in either primary care or hospitals for the TREATMENT patients of any diseases. The task is to critically appraise your chosen guideline. The format: · Table format preferred. · Include consideration of the quality (evidence of critical appraisal) of the references cited in the guideline. · Consider any references missed by the guideline authors. · Include a short summary of your findings. · As a guide the word count may be in the order of 500 to 600 words as the work is intended to be a summary only. Indicate the word count on the front page. · Include one copy of the full print out of the chosen guideline with your work. Other information from course leader: To critically appraise the guideline you need to look at the following:- what data have they used (and referenced to write their guidelines?) Are they randomised controled trials? or expert opinion or animal studies only? By knowing this you can say how reliable evidence based the guidelines are. Have the guidelines used up to date references/ Reputable journal? Known authors? International studies, etc, etc By taking the data used in the guidelines i.e. say they use 10 trials you could create a table with all ten trials listed in the table and see if they satisfy your set criteria? i.e. is the publication less than 5 years old? Are the authors known? Is the journal reputable i.e. high impact factor, etc. I hope this helps? PART TWO Incremental Cost effectiveness ratios (ICER) are used to assist in the determination of which drug in a class is the most cost effective. For example several statins have been compared with respect to cost and efficacy. Cost may be calculated from the total daily dose or from the cost of one month (28 days) treatment using an average dose, i.e. cost of simvastatin 20 mg daily for 28 days . In several publications effectiveness has been measured as the number or people in a group (a percentage of patients) who have achieved a target HDL or total cholesterol level. For example, in an imaginary trial 90% of patients in the atorvastatin treated group reached the treatment target of 3 mmol/L HDl, 77% in the simvastatin treatment group and 45% in the fluvastatin treatment group reached the target HDL level of 3 mmol/L. Thus effectiveness is measured as a % of patients achieving the target. For a fuller explanation refer to the publication:Morrison A & Glassberg H. Determinants of the costeffectiveness of statins. J managed Care Pharmacy 2003; 9:544551. www.amcp.org/data/jmcp/formulary%20Review544551. pdf Another example is the ICER comparison of triptans for migraine. Again cost is calculated either on a daily basis or monthly and effectiveness is measured as the % of patients achieving pain relief within a set time. find the attachment is an example for ICER. when my assibnment become ready to collect. Other assignments deadlines are at the end on January and I will get the feedback of this assignmnet 10 of January. if you need further information contact me on phone or email . Thank you Yousef